The most important procedures are the preparation of aspirin, the recrystallization of aspirin, and the determination of the melting point of aspirin. To make aspirin, acetic anhydride is added to a measured amount of salicylic acid, which is then dried. To bring the reaction to a close, sulphuric acid is introduced and briefly heated.
What is aspirin and how does it work?
Aspirin is a salicylate, which means it has anti-inflammatory properties (sa-LIS-il-ate). It works by lowering the levels of substances in the body that are responsible for pain, fever, and inflammation, among other things.
Aspirin is a pain reliever that also has the added benefit of lowering fever and inflammation. Treatment or prevention of heart attacks, strokes, and chest pain are all possible with this medication (angina).
Aspirin should only be used for cardiovascular conditions under the supervision of a medical professional.
What is the most effective method of taking aspirin?
If you are taking aspirin, follow the directions on the label or the instructions provided by your doctor. Do not use in greater or lesser quantities, or for a longer period of time, than what has been recommended by the manufacturer.
When administering aspirin to a child, always follow the directions on the medication label carefully.
If taking aspirin makes your stomach feel queasy, take it with food.
It is necessary to chew the chewable tablet prior to swallowing it.
Pills that are enteric-coated or delayed/extended-release should not be crushed, chewed, broken, or opened in any way. Take the pill in its entirety.
If you are going to have surgery, make sure the surgeon knows you are taking this medication ahead of time. It is possible that you will have to stop using the product for a short period of time.
It is not recommended to use aspirin if the bottle has a strong vinegar odour. This medication may have ceased to be effective for whatever reason.
Store at room temperature to keep moisture and heat away from the product.
Preparation of Aspirin
Esterification is a type of chemical synthesis that is used to make aspirin.
The reaction of the carboxyl (-COOH) group and the -OH group of a phenol or an alcohol to generate a carboxylate ester is catalysed by acid. The phenolic -OH group is linked to the ring of salicylic acid in the production of aspirin. The acetyl group, -COCH3, derives from acetic anhydride, while sulfuric acid catalyses the process.
This reaction is straightforward and produces a high yield of product. Although aspirin dissolves in hot alcohol, it does not dissolve in water. As a result, the finished product would be filtered from aqueous solution, washed with cold water, and dried in the open air.
Aspirin’s therapeutic component is the salicylate ion. Aspirin does not ionise and create the salicylate ion till it reaches the alkaline environment of the intestines. The acetate and salicylate ions are formed once it is hydrolyzed. The latter ion passes through the intestinal wall and is absorbed.
This reaction is reversed in the last phase of the commercial production of aspirin. Acetic anhydride, a more reactive chemical than the acetate ion, is used to treat salicylic acid. The process is accelerated by catalytic quantities of sulfuric acid. In this assignment, you will perform the synthesis process.
Aspirin has a number of negative effects.
Immediately seek medical attention if you notice any of the following symptoms of an aspirin allergy: Hives, difficulty breathing, and swelling of the face, lips, tongue, or throat are all symptoms of a hives infection.
Immediately stop using this medication and contact your doctor if you experience ringing in your ears, confusion, hallucinations, rapid breathing, seizure (convulsions), severe nausea, vomiting, or stomach pain, bloody or tarry stools, coughing up blood, or vomit that looks like coffee grounds, fever lasting more than 3 days, swelling or pain lasting more than 10 days.
Stomach upset, heartburn, drowsiness, and a mild headache are all possible side effects of taking aspirin.
What other medications will have an impact on the effectiveness of aspirin.
Consult your doctor before taking aspirin if you are taking an antidepressant such as citalopram, escitalopram, fluoxetine (Prozac), fluvoxamine, paroxetine, sertraline (Zoloft), trazodone, or vilazodone, or if you are pregnant or breastfeeding. Any of these medications, when taken in conjunction with an NSAID, may cause you to bruise or bleed more easily.
You should consult your doctor or pharmacist before taking this medication if you are also taking a blood thinner (e.g., warfarin, Coumadin, Jantoven), or any other medication used to prevent blood clots in your body. Nuprin Backache Caplet, Kaopectate, KneeRelief, Pamprin Cramp Formula, Pepto-Bismol, Tricosal, Trilisate, and other salicylates are available.
This is not an all-inclusive list of possible options. Aspirin may interact with a variety of other medications, including prescription and over-the-counter medications, vitamins, and herbal supplements. A comprehensive list of all possible interactions is not included in this medication guide.
Conclusions
CCs had an improved solubility profile when compared to the pure drug and the marketed formulation, according to the findings of this study, which showed 87 percent, 31%, and 60% improvement in solubility profiles when compared to the pure drug and marketed formulation, respectively. When comparing the anti-inflammatory activity of the compound to that of the pure drug, in vivo anti-inflammatory studies revealed an increase. As a result of the findings of this study, we came to the conclusion that cocrystallization has a direct impact on the improvement of physicochemical properties of APIs that have issues such as solubility or stability, with no modification or alteration of their pharmacological actions.
Esterification is a type of chemical synthesis which is used for the preparation of aspirin.